N-acetyl Cysteine Protects Skeletal Muscle from Compartment Syndrome Inducedinjury
نویسنده
چکیده
Swelling in an extremity, when confined by an unyielding constraint such as fascia, may result in impaired circulation in the limb as tissue pressure rises. In clinical practice, fasciotomy remains the only proven treatment of such a compartment syndrome (CS), however this is a procedure associated with significant morbidity and potential mortality. [1]. Establishing the diagnosis of compartment syndrome and timing appropriate surgical intervention remain major challenges in clinical practice. Furthermore delay in diagnosis is consistently reported to be associated with a poor outcome. N-Acetyl cysteine (NAC), a cysteine derivative, is a potent antioxidant that has been in clinical use primarily to reduce hepatocyte injury following acetaminophen overdose. NAC has free radical scavenging properties and is an artificial precursor of glutathione, a critical component of the anti-oxidant shield of skeletal muscle. The aim of this study was to evaluate NAC supplementation in the prevention of compartment syndrome induced skeletal muscle injury.
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